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KMID : 0370219970410010014
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Yakhak Hoeji
1997 Volume.41 No. 1 p.14 ~ p.17
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Design and Synthesis of (+/-)-3-Deoxygericudranin A as an Antitumour Agent
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최윤정/Choi YJ
심필종/김희두/Shim PJ/Kim HD
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Abstract
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(+/-)-3 Deoxygericudranin A was designed and synthesized for the development of novel antitumour agent and for the elucidation of the effect of 3-hydroxyl group in gericudranin A on antitumour activity. 2,4.6-Trihydroxyacetophenone was converted to 3-deoxygericudranin A in 5 steps via sequential protection, aldol condensation, Michael tvpe-cyclization, regioselective, C-benzylation and deprotection.
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